Daminozide is a plant growth regulator and a selective inhibitor of human KDM2/7 histone demethylases. It has IC50s of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide demonstrates over 100-fold selectivity for the KDM2/7 subfamily compared to other demethylase subfamily members tested. It is intended for research use only.
- Plant growth regulator
- Selective inhibitor of human KDM2/7 histone demethylases
- High selectivity for KDM2/7 subfamily (>100-fold)